Representing spatial relationships in posterior parietal cortex: Single neurons code object-referenced position

Matthew V Chafee, Bruno B. Averbeck, David A. Crowe

    Research output: Contribution to journalArticlepeer-review

    65 Scopus citations

    Abstract

    The brain computes spatial relationships as necessary to achieve behavioral goals. Loss of this spatial cognitive ability after damage to posterior parietal cortex may contribute to constructional apraxia, a syndrome in which a patient's ability to reproduce spatial relationships between the parts of an object is disrupted. To explore neural correlates of object-relative spatial representation, we recorded neural activity in parietal area 7a of monkeys performing an object construction task. We found that neurons were activated as a function of the spatial relationship between a task-critical coordinate and a reference object. Individual neurons exhibited an object-relative spatial preference, such that different neural populations were activated when the spatial coordinate was located to the left or right of the reference object. In each case, the representation was robust to translation of the reference object, and neurons maintained their object-relative preference when the position of the object varied relative to the angle of gaze and viewer-centered frames of reference. This provides evidence that the activity of a subpopulation of parietal neurons active in the construction task represented relative position as referenced to an object and not absolute position with respect to the viewer.

    Original languageEnglish (US)
    Pages (from-to)2914-2932
    Number of pages19
    JournalCerebral Cortex
    Volume17
    Issue number12
    DOIs
    StatePublished - Dec 2007

    Bibliographical note

    Funding Information:
    The authors thank Apostolos Georgopoulos for his important intellectual contribution to this work, and for his unfailing support. We thank D. Boeff and D. Evans for expert technical assistance. We thank A. Fortes and A. Basford for comments on the manuscript. This work was supported by United States Public Health Service NIH grant NS17413, the Department of Veterans Affairs, and the American Legion Brain Sciences Chair. Conflict of Interest: None declared.

    Keywords

    • Attention
    • Constructional apraxia
    • Hemispatial neglect
    • Monkey
    • Object-centered

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