Reproductive and developmental toxicity of potassium perfluorohexanesulfonate in CD-1 mice

Sue Chang, John L. Butenhoff, George A. Parker, Prägati S. Coder, Jeremiah D. Zitzow, Ryan M. Krisko, James A. Bjork, Kendall B. Wallace, Jennifer G. Seed

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Potassium perfluorohexanesulfonate (K+PFHxS) was evaluated for reproductive/developmental toxicity in CD-1 mice. Up to 3 mg/kg-d K+PFHxS was administered (n = 30/sex/group) before mating, for at least 42 days in F0 males, and for F0 females, through gestation and lactation. F1 pups were directly dosed with K+PFHxS for 14 days after weaning. There was an equivocal decrease in live litter size at 1 and 3 mg/kg-d, but the pup-born-to-implant ratio was unaffected. Adaptive hepatocellular hypertrophy was observed, and in 3 mg/kg-d F0 males, it was accompanied by concomitant decreased serum cholesterol and increased alkaline phosphatase. There were no other toxicologically significant findings on reproductive parameters, hematology/clinical pathology/TSH, neurobehavioral effects, or histopathology. There were no treatment-related effects on postnatal survival, development, or onset of preputial separation or vaginal opening in F1 mice. Consistent with previous studies, our data suggest that the potency of PFHxS is much lower than PFOS in rodents.

Original languageEnglish (US)
Pages (from-to)150-168
Number of pages19
JournalReproductive Toxicology
Volume78
DOIs
StatePublished - Jun 2018

Bibliographical note

Publisher Copyright:
© 2018 The Authors

Keywords

  • Cholesterol
  • Developmental
  • Liver
  • Mice
  • PFHxS
  • Perfluorohexanesulfonate
  • Reproductive
  • Thyroid

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