Resolution of (±)‐Propranolol

Yul Yost, Jordan L. Holtzman

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


Two improvements in propranolol resolution were developed. Both the (+)‐ and (‐)‐di‐(p‐toluoyl)tartaric acids were used as the resolving agents. This procedure reduced the number of crystallizations needed to obtain a pure product. Furthermore, synthesis of the resolving agent was improved.

Original languageEnglish (US)
Pages (from-to)1181-1182
Number of pages2
JournalJournal of Pharmaceutical Sciences
Issue number9
StatePublished - Sep 1979


  • Enantiomers—propranolol, resolving agents
  • Propranolol—racemic mixtures, resolution of enantiomers,.(+)‐ and (‐)‐di‐(p‐toluoyl)tartaric acids used as resolving agents

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