TY - JOUR
T1 - Respiratory sinus arrhythmia is associated with efficiency of pulmonary gas exchange in healthy humans
AU - Giardino, Nicholas D.
AU - Glenny, Robb W.
AU - Borson, Soo
AU - Chan, Leighton
PY - 2003/5/1
Y1 - 2003/5/1
N2 - Respiratory sinus arrhythmia (RSA) may be associated with improved efficiency of pulmonary gas exchange by matching ventilation to perfusion within each respiratory cycle. Respiration rate, tidal volume, minute ventilation (V̇E), exhaled carbon dioxide (V̇CO2), oxygen consumption (V̇o2), and heart rate were measured in 10 healthy human volunteers during paced breathing to test the hypothesis that RSA contributes to pulmonary gas exchange efficiency. Cross-spectral analysis of heart rate and respiration was computed to calculate RSA and the coherence and phase between these variables. Pulmonary gas exchange efficiency was measured as the average ventilatory equivalent of CO2 (V̇E/V̇CO2) and O2 (V̇E/V̇O2). Across subjects and paced breathing periods, RSA was significantly associated with CO2 (partial r = -0.53, P = 0.002) and O2 (partial r = -0.49, P = 0.005) exchange efficiency after controlling for the effects of age, respiration rate, tidal volume, and average heart rate. Phase between heart rate and respiration was significantly associated with CO2 exchange efficiency (partial r = 0.40, P = 0.03). These results are consistent with previous studies and further support the theory that RSA may improve the efficiency of pulmonary gas exchange.
AB - Respiratory sinus arrhythmia (RSA) may be associated with improved efficiency of pulmonary gas exchange by matching ventilation to perfusion within each respiratory cycle. Respiration rate, tidal volume, minute ventilation (V̇E), exhaled carbon dioxide (V̇CO2), oxygen consumption (V̇o2), and heart rate were measured in 10 healthy human volunteers during paced breathing to test the hypothesis that RSA contributes to pulmonary gas exchange efficiency. Cross-spectral analysis of heart rate and respiration was computed to calculate RSA and the coherence and phase between these variables. Pulmonary gas exchange efficiency was measured as the average ventilatory equivalent of CO2 (V̇E/V̇CO2) and O2 (V̇E/V̇O2). Across subjects and paced breathing periods, RSA was significantly associated with CO2 (partial r = -0.53, P = 0.002) and O2 (partial r = -0.49, P = 0.005) exchange efficiency after controlling for the effects of age, respiration rate, tidal volume, and average heart rate. Phase between heart rate and respiration was significantly associated with CO2 exchange efficiency (partial r = 0.40, P = 0.03). These results are consistent with previous studies and further support the theory that RSA may improve the efficiency of pulmonary gas exchange.
KW - Heart rate variability
KW - Phase
KW - Ventilatory equivalent
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U2 - 10.1152/ajpheart.00893.2002
DO - 10.1152/ajpheart.00893.2002
M3 - Article
C2 - 12543637
AN - SCOPUS:0345700664
SN - 0363-6135
VL - 284
SP - H1585-H1591
JO - American Journal of Physiology - Heart and Circulatory Physiology
JF - American Journal of Physiology - Heart and Circulatory Physiology
IS - 5 53-5
ER -