Return of bradykinesia after subthalamic stimulation ceases: Relationship to electrode location

Scott Evan Cooper, Angela Marie Noecker, Hesham Abboud, Jerrold Lee Vitek, Cameron Charles McIntyre

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

In 20 subjects we quantified the rate at which subthalamic nucleus deep brain stimulation effects on Parkinson's bradykinesia "washed-out" after stimulation ceased. We found that wash-out was a two-step process, consisting of an initial fast decrease in stimulation's therapeutic effect, followed by a further, slow decline. Moreover, the relative contribution of the fast and slow components differed between patients. Finally, we found that lateral stimulation caused more of the fast-decaying component, while medial stimulation caused more of the slow-decaying component. This implies the existence of at least two separate mechanisms by which subthalamic nucleus deep brain stimulation improves bradykinesia, associated with activation of spatially separate zones in the vicinity of the subthalamic nucleus.

Original languageEnglish (US)
Pages (from-to)207-213
Number of pages7
JournalExperimental Neurology
Volume231
Issue number2
DOIs
StatePublished - Oct 2011

Bibliographical note

Copyright:
Copyright 2011 Elsevier B.V., All rights reserved.

Keywords

  • Deep brain stimulation
  • Parkinson's
  • Plasticity
  • Subthalamic nucleus
  • Zona incerta

Fingerprint

Dive into the research topics of 'Return of bradykinesia after subthalamic stimulation ceases: Relationship to electrode location'. Together they form a unique fingerprint.

Cite this