TY - JOUR
T1 - Seasonal Incidence of Phenytoin Allergy Unrelated to Plasma Levels
AU - Leppik, Ilo E
AU - Lapora, Judy
AU - Loewenson, Ruth
PY - 1985/2
Y1 - 1985/2
N2 - In a three-year prospective study of patients to whom phenytoin was administered, 26 (8.5%) of 306 patients manifested an erythematous morbiliform rash within three weeks of onset of therapy. Occurrence of the rash was not related to the mode of administration of treatment (loading v maintenance) or initial phenytoin levels. A striking seasonal incidence of the rash was noted: None of the 79 persons who received the initial dose during December to February had a reaction, whereas 13 (20.6%) of 63 persons treated during June to August manifested the rash. For March to May, the rate was 10% (8/88), and for September to November, 6.7% (5/76). Monthly rates were significantly different by ϰ2 test.
AB - In a three-year prospective study of patients to whom phenytoin was administered, 26 (8.5%) of 306 patients manifested an erythematous morbiliform rash within three weeks of onset of therapy. Occurrence of the rash was not related to the mode of administration of treatment (loading v maintenance) or initial phenytoin levels. A striking seasonal incidence of the rash was noted: None of the 79 persons who received the initial dose during December to February had a reaction, whereas 13 (20.6%) of 63 persons treated during June to August manifested the rash. For March to May, the rate was 10% (8/88), and for September to November, 6.7% (5/76). Monthly rates were significantly different by ϰ2 test.
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U2 - 10.1001/archneur.1985.04060020030009
DO - 10.1001/archneur.1985.04060020030009
M3 - Article
C2 - 3977636
AN - SCOPUS:0022001388
SN - 0003-9942
VL - 42
SP - 120
EP - 122
JO - Archives of Neurology
JF - Archives of Neurology
IS - 2
ER -