Seasonal Incidence of Phenytoin Allergy Unrelated to Plasma Levels

Ilo E Leppik, Judy Lapora, Ruth Loewenson

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


In a three-year prospective study of patients to whom phenytoin was administered, 26 (8.5%) of 306 patients manifested an erythematous morbiliform rash within three weeks of onset of therapy. Occurrence of the rash was not related to the mode of administration of treatment (loading v maintenance) or initial phenytoin levels. A striking seasonal incidence of the rash was noted: None of the 79 persons who received the initial dose during December to February had a reaction, whereas 13 (20.6%) of 63 persons treated during June to August manifested the rash. For March to May, the rate was 10% (8/88), and for September to November, 6.7% (5/76). Monthly rates were significantly different by ϰ2 test.

Original languageEnglish (US)
Pages (from-to)120-122
Number of pages3
JournalArchives of Neurology
Issue number2
StatePublished - Feb 1985

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