TY - JOUR
T1 - Sensing your surroundings
T2 - how transcription-regulatory networks of the cell discern environmental signals.
AU - Balázsi, Gábor
AU - Oltvai, Zoltán N.
PY - 2005/5/3
Y1 - 2005/5/3
N2 - Accumulating evidence indicates that cells differentially regulate parts of their biochemical networks in various environmental conditions. Two recent studies, focused on the yeast transcription-regulatory network, have identified the characteristics and some of the regulatory logic that defines such conditional regulation on a system level. But what is the underlying basis of such environment-dependent dynamic network utilization? We propose that with simultaneous changes in many environmental variables, cells detect and process the incoming pieces of information individually with the use of receptors and sensor transcription factors specialized to a given type of signal. In turn, transcriptional subnetworks affected by the activity of these proteins reassemble the processed signals deeper inside the network, ultimately resulting in the development of an integrated cellular response.
AB - Accumulating evidence indicates that cells differentially regulate parts of their biochemical networks in various environmental conditions. Two recent studies, focused on the yeast transcription-regulatory network, have identified the characteristics and some of the regulatory logic that defines such conditional regulation on a system level. But what is the underlying basis of such environment-dependent dynamic network utilization? We propose that with simultaneous changes in many environmental variables, cells detect and process the incoming pieces of information individually with the use of receptors and sensor transcription factors specialized to a given type of signal. In turn, transcriptional subnetworks affected by the activity of these proteins reassemble the processed signals deeper inside the network, ultimately resulting in the development of an integrated cellular response.
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U2 - 10.1126/stke.2822005pe20
DO - 10.1126/stke.2822005pe20
M3 - Review article
C2 - 15870424
AN - SCOPUS:30344444644
SN - 1937-9145
VL - 2005
SP - pe20
JO - Science's STKE : signal transduction knowledge environment
JF - Science's STKE : signal transduction knowledge environment
IS - 282
ER -