Abstract
Background: Genome-scale draft metabolic networks are incomplete, even for well studied organisms. Results: Reactions selected by minimizing flux through unlikely reactions resulted in networks of superior quality. Conclusion: Genome-scale models have many network completion solutions but require the addition of unsupported reactions to be functional. Significance: Metabolic networks guide synthetic biology efforts, and the quality of networks determines their predictive power.
Original language | English (US) |
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Pages (from-to) | 19197-19207 |
Number of pages | 11 |
Journal | Journal of Biological Chemistry |
Volume | 290 |
Issue number | 31 |
DOIs | |
State | Published - Jul 31 2015 |
Bibliographical note
Publisher Copyright:© 2015 by The American Society for Biochemistry and Molecular Biology, Inc.