Serum cholesterol concentration and primary malignant brain tumors: A prospective study

George Davey Smith, James D. Neaton, Yoav Ben-shlomo, Martin Shipley, Deborah Wentworth

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Case-control studies and a prospective study have suggested a positive relation between serum cholesterol and brain tumors. To examine this association further, mortality from malignant brain tumors among men who participated in the Multiple Risk Factor Intervention Trial (a prospective study, 1973-1986) who indicated they were not black were examined. No relation was seen between age-standardized mortality rates and baseline serum cholesterol. Excluding deaths occurring during the first 5 years or adjusting for median census tract income did not alter this finding. This suggests that no generalizabte relation between serum cholesterol and primary malignant brain tumors exists. An environmental factor associated with serum cholesterol in some, but not all populations, may explain the apparently contradictory results. Am J Epidemiol 1992;135:259-65.

Original languageEnglish (US)
Pages (from-to)259-265
Number of pages7
JournalAmerican journal of epidemiology
Volume135
Issue number3
DOIs
StatePublished - Feb 1 1992

Bibliographical note

Funding Information:
We are grateful to the principal investigators and other staff of the clinical, coordinating, and support center of the Multiple Risk Factor Intervention Trial. The Multiple Risk Factor Intervention Trial was sponsored by the National Heart, Lung, and Hood Institute.

Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.

Keywords

  • Brain neoplasms
  • Cholesterol
  • Prospective studies

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