TY - JOUR
T1 - Simulation of selective pulse techniques for localized NMR spectroscopy
AU - Garwood, Michael
AU - Schleich, Thomas
AU - Robin Bendall, M.
N1 - Funding Information:
‘We thank Dr. G. B. Matson for helpful discussions. This work was supportebdy NIH Grant EY 04033.
PY - 1987/6/15
Y1 - 1987/6/15
N2 - The results of a computer simulation investigation delineating the limits of resolution, sensitivity, and accuracy of the depth-resolved suface-coil spectroscopy (DRESS), volume-selective excitation (VSE), and image-selected in vivo spectroscopy (ISIS) methods for achieving spatially localized NMR spectroscopy are presented. A computer program, which numerically solves the Bloch equations for variable input parameters, is used to simulate the spatial localization afforded by each technique. Because the numerical solution of the Bloch equations describes the behavior of the bulk magnetization with great precision, the simulations provide an objective and realistic means of evaluating the performance of the individual localization schemes and reveal nuances and limitations not discussed in the original experimental papers. The results of this computer simulation study should encourage the optimization of localization methodology for use in specific applications.
AB - The results of a computer simulation investigation delineating the limits of resolution, sensitivity, and accuracy of the depth-resolved suface-coil spectroscopy (DRESS), volume-selective excitation (VSE), and image-selected in vivo spectroscopy (ISIS) methods for achieving spatially localized NMR spectroscopy are presented. A computer program, which numerically solves the Bloch equations for variable input parameters, is used to simulate the spatial localization afforded by each technique. Because the numerical solution of the Bloch equations describes the behavior of the bulk magnetization with great precision, the simulations provide an objective and realistic means of evaluating the performance of the individual localization schemes and reveal nuances and limitations not discussed in the original experimental papers. The results of this computer simulation study should encourage the optimization of localization methodology for use in specific applications.
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U2 - 10.1016/0022-2364(87)90191-0
DO - 10.1016/0022-2364(87)90191-0
M3 - Article
AN - SCOPUS:0347197388
SN - 0022-2364
VL - 73
SP - 191
EP - 212
JO - Journal of Magnetic Resonance (1969)
JF - Journal of Magnetic Resonance (1969)
IS - 2
ER -