Slow Receptor Binding of the Noncytopathic HIV-2UC1 Envs Is Balanced by Long-Lived Activation State and Efficient Fusion Activity

Miranda Harris; Sneha Ratnapriya; Angela Chov; Héctor Cervera; Alisha Block; Christopher Gu; Nathaniel Talledge; Louis M. Mansky; Joseph Sodroski; Alon Herschhorn

doi:10.1016/j.celrep.2020.107749

Slow Receptor Binding of the Noncytopathic HIV-2_UC1 Envs Is Balanced by Long-Lived Activation State and Efficient Fusion Activity

Miranda Harris, Sneha Ratnapriya, Angela Chov, Héctor Cervera, Alisha Block, Christopher Gu, Nathaniel Talledge, Louis M. Mansky, Joseph Sodroski, Alon Herschhorn

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Harris et al. show that the envelope glycoproteins of a rare HIV-2_UC1 strain evolved to balance low affinity to the CD4 receptor with an improved, long-lived, and readily triggerable molecular machinery to mediate virus entry.

Original language	English (US)
Article number	107749
Journal	Cell reports
Volume	31
Issue number	10
DOIs	https://doi.org/10.1016/j.celrep.2020.107749
State	Published - Jun 9 2020

Bibliographical note

Publisher Copyright:
© 2020 The Author(s)

Keywords

HIV envelope glycoproteins
binding kinetics
long-lived activation state
molecular mechanism of HIV entry

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10.1016/j.celrep.2020.107749

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