TY - JOUR
T1 - Slow virus visna
T2 - Reproduction in vitro of virus from extrachromosomal DNA
AU - Harris, J. D.
AU - Blum, H.
AU - Scott, J.
AU - Traynor, B.
AU - Ventura, P.
AU - Haase, A.
PY - 1984
Y1 - 1984
N2 - Under permissive conditions of growth in tissue culture, the retrovirus visna multiplies over the course of a few days to high titer and kills the host cell. We show that in this lytic life cycle, viral DNA is tightly associated with, but not covalently linked to, chromosomal DNA. This finding provides explanations for a number of the unusual properties of the lentivirus subfamily of retroviruses, and suggests potential mechanisms for the block in virus gene expression in vivo responsible for the slow infection in nature.
AB - Under permissive conditions of growth in tissue culture, the retrovirus visna multiplies over the course of a few days to high titer and kills the host cell. We show that in this lytic life cycle, viral DNA is tightly associated with, but not covalently linked to, chromosomal DNA. This finding provides explanations for a number of the unusual properties of the lentivirus subfamily of retroviruses, and suggests potential mechanisms for the block in virus gene expression in vivo responsible for the slow infection in nature.
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U2 - 10.1073/pnas.81.22.7212
DO - 10.1073/pnas.81.22.7212
M3 - Article
C2 - 6095275
AN - SCOPUS:0343322295
SN - 0027-8424
VL - 81
SP - 7212
EP - 7215
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 22 I
ER -