Solid-phase synthesis of C-terminal peptide libraries for studying the specificity of enzymatic protein prenylation

Yen Chih Wang, Mark D. Distefano

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Prenylation is an essential post-translational modification in all eukaryotes. Here we describe the synthesis of a 340-member library of peptides containing free C-termini on cellulose membranes. The resulting library was then used to probe the specificity of protein farnesyltransferase from S. cerevisiae.

Original languageEnglish (US)
Pages (from-to)8228-8230
Number of pages3
JournalChemical Communications
Volume48
Issue number66
DOIs
StatePublished - Jul 23 2012

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