TY - JOUR
T1 - Spinal cord injury-induced osteoporosis
T2 - Pathogenesis and emerging therapies
AU - Battaglino, Ricardo A.
AU - Lazzari, Antonio A.
AU - Garshick, Eric
AU - Morse, Leslie R.
PY - 2012/12/1
Y1 - 2012/12/1
N2 - Spinal cord injury causes rapid, severe osteoporosis with increased fracture risk. Mechanical unloading after paralysis results in increased osteocyte expression of sclerostin, suppressed bone formation, and indirect stimulation of bone resorption. At this time, there are no clinical guidelines to prevent bone loss after SCI, and fractures are common. More research is required to define the pathophysiology and epidemiology of SCI-induced osteoporosis. This review summarizes emerging therapeutics including antisclerostin antibodies, mechanical loading of the lower extremity with electrical stimulation, and mechanical stimulation via vibration therapy.
AB - Spinal cord injury causes rapid, severe osteoporosis with increased fracture risk. Mechanical unloading after paralysis results in increased osteocyte expression of sclerostin, suppressed bone formation, and indirect stimulation of bone resorption. At this time, there are no clinical guidelines to prevent bone loss after SCI, and fractures are common. More research is required to define the pathophysiology and epidemiology of SCI-induced osteoporosis. This review summarizes emerging therapeutics including antisclerostin antibodies, mechanical loading of the lower extremity with electrical stimulation, and mechanical stimulation via vibration therapy.
KW - Bone mineral density
KW - Mechanical unloading
KW - Osteoporosis
KW - Sclerostin
KW - Spinal cord injury
UR - http://www.scopus.com/inward/record.url?scp=84872173266&partnerID=8YFLogxK
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U2 - 10.1007/s11914-012-0117-0
DO - 10.1007/s11914-012-0117-0
M3 - Article
C2 - 22983921
AN - SCOPUS:84872173266
SN - 1544-1873
VL - 10
SP - 278
EP - 285
JO - Current Osteoporosis Reports
JF - Current Osteoporosis Reports
IS - 4
ER -