Spurious Hyperphosphatemia in a Dog With Chronic Lymphocytic Leukemia and an IgM Monoclonal Gammopathy

Annemarie T. Kristensen, Jeffrey S. Klausner, Douglas J. Weiss, Ronald D. Schultz, Ford W. Bell

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Spurious hyperphosphatemia was diagnosed in a 6‐year‐old, neutered female, mixed‐breed dog with chronic lymphocytic leukemia associated with an IgM monoclonal gammopathy. The spurious hyperphosphatemia was probably caused by paraprotein precipitation which interfered with the ASTRA 8 automated analyzer measurements. Serial dilutions of the sample did not change the phosphorus value. Another analyzer system in which a protein‐free sample was prepared prior to analysis gave a normal serum phosphorus concentration. There was a linear relationship between the amount of paraprotein and the measured total serum inorganic phosphate (r = 0.75). A review of 700 chemistry profiles from dogs and cats and a review of 36 cases with polyclonal gammopathy and 6 cases with monoclonal gammopathy did not reveal other cases of spurious hyperphosphatemia.

Original languageEnglish (US)
Pages (from-to)45-50
Number of pages6
JournalVeterinary Clinical Pathology
Volume20
Issue number2
DOIs
StatePublished - Jun 1991

Keywords

  • chronic lymphocytic leukemia
  • hyperphosphatemia
  • paraproteinemia
  • spurious

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