Stability of streptococcal pyrogenic exotoxin production with laboratory manipulation of group A streptococci

Edward L. Kaplan; Dwight R. Johnson; Anthony Wlazlo; Michael H. Kim; Patrick M. Schlievert

doi:10.1093/infdis/164.6.1210

Stability of streptococcal pyrogenic exotoxin production with laboratory manipulation of group A streptococci

Edward L. Kaplan, Dwight R. Johnson, Anthony Wlazlo, Michael H. Kim, Patrick M. Schlievert

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Abstract

Because of reported differences in the production of streptococcal pyrogenic exotoxins by group A strains associated with severe streptococcal infections, the stability of exotoxin production by specific strains was examined by passing group A streptococci on blood agar culture plates daily for 20 days. No changes were detected in either exotoxin genes or in exotoxin production during this time, suggesting that these reported differences are due to other explanations such as differences in the strains collected from various geographic areas or to laboratory methodologic differences.

Original language	English (US)
Pages (from-to)	1210-1211
Number of pages	2
Journal	Journal of Infectious Diseases
Volume	164
Issue number	6
DOIs	https://doi.org/10.1093/infdis/164.6.1210
State	Published - Dec 1991

Bibliographical note

Funding Information:
Received 7 May 1991; revised I7 July 1991. Grant support: Emma B. Howe Foundation and National Institutes of Health (HL-36611). Reprints or correspondence: Dr. Edward L. Kaplan, Department ofPediatrics, Box 296 UMHC, University ofMinnesota Medical School, 420 Delaware St. S.E., Minneapolis, MN 55455.

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abstract = "Because of reported differences in the production of streptococcal pyrogenic exotoxins by group A strains associated with severe streptococcal infections, the stability of exotoxin production by specific strains was examined by passing group A streptococci on blood agar culture plates daily for 20 days. No changes were detected in either exotoxin genes or in exotoxin production during this time, suggesting that these reported differences are due to other explanations such as differences in the strains collected from various geographic areas or to laboratory methodologic differences.",

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Stability of streptococcal pyrogenic exotoxin production with laboratory manipulation of group A streptococci

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