Steerable nanobots for diagnosis and therapy

Anirudh Sharma; Yuechen Zhu; Madhukar Reddy; Allison Hubel; Ryan Cobian; Liwen Tan; Bethanie Stadler

doi:10.1007/978-3-319-02207-9_18

Steerable nanobots for diagnosis and therapy

Anirudh Sharma, Yuechen Zhu, Madhukar Reddy, Allison Hubel, Ryan Cobian, Liwen Tan, Bethanie Stadler

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

1 Scopus citations

Abstract

This paper reviews the synthesis of magnetic multilayerd nanowires that have a wide range of applications. Specifically of interest in this review are the applications of magnetic manipulation and separation of cells, which are important for potential cancer therapies. Compared to other magnetic nanoparticles in use today, the nanowires have the advantage of being ferromagnetic and also having high aspect ratios that enable barcoding. These nanobots are synthesized inside nanoporous oxide templates in large batches (10¹² per square inch), and they can be composed of any magnetic metal, alloy, or multilayer that can be electroplated. Specific details for the electrochemistry of Galfenol deposition are given. Galfenol is an exciting new magnetostrictive material with durable mechanical properties. Next, a protocol is described for full removal of the growth contact prior to release of the nanobots from their oxide template. This mitigates aggregation which inhibits cellular uptake. Feasibility of manipulation and separation was shown using canine bone cancer (os-teosarcoma) cells which internalized the nanobots, enabling magnetic cellular control. In addition, initial toxicity studies indicate that the nanobots are not cytotoxic. These studies merely scratch the surface of the potential use of nanobots for diagnosis and therapy in the near future.

Original language	English (US)
Title of host publication	Universe of Scales
Subtitle of host publication	From Nanotechnology to Cosmology - Symposium in Honor of Minoru M. Freund
Editors	Friedemann Freund, Stephanie Langhoff
Publisher	Springer Science and Business Media, LLC
Pages	179-189
Number of pages	11
ISBN (Print)	9783319022062
DOIs	https://doi.org/10.1007/978-3-319-02207-9_18
State	Published - Jan 1 2014
Event	Universe of Scales: From Nanotechnology to Cosmology Symposium in Honor of Minoru M. Freund, 2014 - Moffett Field, United States Duration: Jan 1 2014 → …

Publication series

Name	Springer Proceedings in Physics
Volume	150
ISSN (Print)	0930-8989
ISSN (Electronic)	1867-4941

Conference

Conference	Universe of Scales: From Nanotechnology to Cosmology Symposium in Honor of Minoru M. Freund, 2014
Country	United States
City	Moffett Field
Period	1/1/14 → …

UN SDGs

This output contributes to the following Sustainable Development Goal(s)

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Sharma, A., Zhu, Y., Reddy, M., Hubel, A., Cobian, R., Tan, L., & Stadler, B. (2014). Steerable nanobots for diagnosis and therapy. In F. Freund, & S. Langhoff (Eds.), Universe of Scales: From Nanotechnology to Cosmology - Symposium in Honor of Minoru M. Freund (pp. 179-189). (Springer Proceedings in Physics; Vol. 150). Springer Science and Business Media, LLC. https://doi.org/10.1007/978-3-319-02207-9_18

Steerable nanobots for diagnosis and therapy. / Sharma, Anirudh; Zhu, Yuechen; Reddy, Madhukar; Hubel, Allison; Cobian, Ryan; Tan, Liwen; Stadler, Bethanie.

Universe of Scales: From Nanotechnology to Cosmology - Symposium in Honor of Minoru M. Freund. ed. / Friedemann Freund; Stephanie Langhoff. Springer Science and Business Media, LLC, 2014. p. 179-189 (Springer Proceedings in Physics; Vol. 150).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Sharma, A, Zhu, Y, Reddy, M, Hubel, A, Cobian, R, Tan, L & Stadler, B 2014, Steerable nanobots for diagnosis and therapy. in F Freund & S Langhoff (eds), Universe of Scales: From Nanotechnology to Cosmology - Symposium in Honor of Minoru M. Freund. Springer Proceedings in Physics, vol. 150, Springer Science and Business Media, LLC, pp. 179-189, Universe of Scales: From Nanotechnology to Cosmology Symposium in Honor of Minoru M. Freund, 2014, Moffett Field, United States, 1/1/14. https://doi.org/10.1007/978-3-319-02207-9_18

Sharma A, Zhu Y, Reddy M, Hubel A, Cobian R, Tan L et al. Steerable nanobots for diagnosis and therapy. In Freund F, Langhoff S, editors, Universe of Scales: From Nanotechnology to Cosmology - Symposium in Honor of Minoru M. Freund. Springer Science and Business Media, LLC. 2014. p. 179-189. (Springer Proceedings in Physics). https://doi.org/10.1007/978-3-319-02207-9_18

Sharma, Anirudh ; Zhu, Yuechen ; Reddy, Madhukar ; Hubel, Allison ; Cobian, Ryan ; Tan, Liwen ; Stadler, Bethanie. / Steerable nanobots for diagnosis and therapy. Universe of Scales: From Nanotechnology to Cosmology - Symposium in Honor of Minoru M. Freund. editor / Friedemann Freund ; Stephanie Langhoff. Springer Science and Business Media, LLC, 2014. pp. 179-189 (Springer Proceedings in Physics).

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