Stimulation of secondary anti-MSV cytolytic T lymphocytes with MBL-2 reconstituted membranes

V. Duprez, M. F. Mescher, S. J. Burakoff

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Membranes and solubilized, reconstituted membranes from Moloney-infected tumors MBL-2 have been used to stimulate in vitro secondary cytolytic T lymphocytes (CTL) in C57BL/6 mice primed with Moloney murine sarcoma virus. Membranes are shown to stimulate the generation of Moloney-specific and H-2 restricted CTL. Stimulation with solubilized, reconstituted membranes required the presence of rat lymphocyte Con A supernatant (containing interleukin 2) during culture. Reconstituted membranes made in the presence of a detergent-insoluble fraction from the plasma membrane were able to stimulate a response in the absence of Con A supernatant.

Original languageEnglish (US)
Pages (from-to)493-495
Number of pages3
JournalJournal of Immunology
Volume130
Issue number1
StatePublished - 1983

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