TY - JOUR
T1 - Stromal and hematopoietic cells in secondary lymphoid organs
T2 - Partners in immunity
AU - Malhotra, Deepali
AU - Fletcher, Anne L.
AU - Turley, Shannon J.
PY - 2013/1
Y1 - 2013/1
N2 - Secondary lymphoid organs (SLOs), including lymph nodes, Peyer's patches, and the spleen, have evolved to bring cells of the immune system together. In these collaborative environments, lymphocytes scan the surfaces of antigen-presenting cells for cognate antigens, while moving along stromal networks. The cell-cell interactions between stromal and hematopoietic cells in SLOs are therefore integral to the normal functioning of these tissues. Not only do stromal cells physically construct SLO architecture but they are essential for regulating hematopoietic populations within these domains. Stromal cells interact closely with lymphocytes and dendritic cells, providing scaffolds on which these cells migrate, and recruiting them into niches by secreting chemokines. Within lymph nodes, stromal cell-ensheathed conduit networks transport small antigens deep into the SLO parenchyma. More recently, stromal cells have been found to induce peripheral CD8+ T-cell tolerance and control the extent to which newly activated T cells proliferate within lymph nodes. Thus, stromal-hematopoietic crosstalk has important consequences for regulating immune cell function within SLOs. In addition, stromal cell interactions with hematopoietic cells, other stroma, and the inflammatory milieu have profound effects on key stromal functions. Here, we examine ways in which these interactions within the lymph node environment influence the adaptive immune response.
AB - Secondary lymphoid organs (SLOs), including lymph nodes, Peyer's patches, and the spleen, have evolved to bring cells of the immune system together. In these collaborative environments, lymphocytes scan the surfaces of antigen-presenting cells for cognate antigens, while moving along stromal networks. The cell-cell interactions between stromal and hematopoietic cells in SLOs are therefore integral to the normal functioning of these tissues. Not only do stromal cells physically construct SLO architecture but they are essential for regulating hematopoietic populations within these domains. Stromal cells interact closely with lymphocytes and dendritic cells, providing scaffolds on which these cells migrate, and recruiting them into niches by secreting chemokines. Within lymph nodes, stromal cell-ensheathed conduit networks transport small antigens deep into the SLO parenchyma. More recently, stromal cells have been found to induce peripheral CD8+ T-cell tolerance and control the extent to which newly activated T cells proliferate within lymph nodes. Thus, stromal-hematopoietic crosstalk has important consequences for regulating immune cell function within SLOs. In addition, stromal cell interactions with hematopoietic cells, other stroma, and the inflammatory milieu have profound effects on key stromal functions. Here, we examine ways in which these interactions within the lymph node environment influence the adaptive immune response.
KW - Blood endothelial cell
KW - Dendritic cell
KW - Fibroblastic reticular cell
KW - Integrin α pericyte
KW - Lymphatic endothelial cell
KW - T cell
KW - Tolerance/suppression
UR - http://www.scopus.com/inward/record.url?scp=84871424854&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84871424854&partnerID=8YFLogxK
U2 - 10.1111/imr.12023
DO - 10.1111/imr.12023
M3 - Article
C2 - 23278748
AN - SCOPUS:84871424854
SN - 0105-2896
VL - 251
SP - 160
EP - 176
JO - Immunological Reviews
JF - Immunological Reviews
IS - 1
ER -