Structure-activity analysis of the Pseudomonas quinolone signal molecule

James Hodgkinson, Steven D. Bowden, Warren R J D Galloway, David R. Spring, Martin Welch

Research output: Contribution to journalArticlepeer-review

39 Scopus citations

Abstract

We synthesized a range of PQS (Pseudomonas quinolone signal; 2-heptyl-3-hydroxy-4(1H)-quinolone) analogues and tested them for their ability to stimulate MvfR-dependent pqsA transcription, MvfR-independent pyoverdine production, and membrane vesicle production. The structure-activity profile of the PQS analogues was different for each of these phenotypes. Certain inactive PQS analogues were also found to strongly synergize PQS-dependent pyoverdine production.

Original languageEnglish (US)
Pages (from-to)3833-3837
Number of pages5
JournalJournal of bacteriology
Volume192
Issue number14
DOIs
StatePublished - Jul 2010

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