Structure-activity relationships for human estrogenic activity in zearalenone mycotoxins

W. T. Shier, A. C. Shier, W. Xie, C. J. Mirocha

Research output: Contribution to journalArticlepeer-review

217 Scopus citations

Abstract

Zearalenones are estrogenic Fusarium mycotoxins consisting of a resorcinol moiety fused to a 14-member macrocyclic lactone. Using an improved MCF7 human breast cell proliferation assay, we have compared the estrogenicity of 17 chromatographically-homogeneous zearalenones. Both similarities and substantial differences from published results in intact animal systems were observed. Substantial human estrogenicity was retained even in analogs lacking hydroxylation on the aromatic and macrocyclic rings.

Original languageEnglish (US)
Pages (from-to)1435-1438
Number of pages4
JournalToxicon
Volume39
Issue number9
DOIs
StatePublished - 2001

Bibliographical note

Funding Information:
This research was supported in part by NRICGP research grant 96-35201-3271 from the United States Department of Agriculture.

Keywords

  • Estradiol
  • Estrogenicity
  • Fusarium mycotoxins
  • Structure-activity relationships
  • Zearalenone

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