Studies of peptidergic input to the lateral spinal nucleus

Kenneth D. Cliffer; Gideon Urca; Robert P. Elde; Glenn J. Giesler

doi:10.1016/0006-8993(88)90381-2

Studies of peptidergic input to the lateral spinal nucleus

Kenneth D. Cliffer, Gideon Urca, Robert P. Elde, Glenn J. Giesler

Neuroscience

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25 Scopus citations

Abstract

Lesions were made to interrupt potential sources of peptidergic input to the lateral spinal nucleus (LSn) in rats. Rhizotomies and spinal transections, as well as lesions of the lateral funiculus, failed to reduce immunohistochemical staining for substance P, dynorphin_1-8, Met-enkephalin, somatostatin and FMRF-amide in the LSn at lumbar levels. Thus, all examined peptidergic afferent input to the LSn appears to originate locally within the spinal cord.

Original language	English (US)
Pages (from-to)	356-360
Number of pages	5
Journal	Brain Research
Volume	460
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(88)90381-2
State	Published - Sep 20 1988

Keywords

Dynorphin
Enkephalin
Lateral spinal nucleus
Peptide
Somatostatin
Substance P

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title = "Studies of peptidergic input to the lateral spinal nucleus",

abstract = "Lesions were made to interrupt potential sources of peptidergic input to the lateral spinal nucleus (LSn) in rats. Rhizotomies and spinal transections, as well as lesions of the lateral funiculus, failed to reduce immunohistochemical staining for substance P, dynorphin1-8, Met-enkephalin, somatostatin and FMRF-amide in the LSn at lumbar levels. Thus, all examined peptidergic afferent input to the LSn appears to originate locally within the spinal cord.",

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AB - Lesions were made to interrupt potential sources of peptidergic input to the lateral spinal nucleus (LSn) in rats. Rhizotomies and spinal transections, as well as lesions of the lateral funiculus, failed to reduce immunohistochemical staining for substance P, dynorphin1-8, Met-enkephalin, somatostatin and FMRF-amide in the LSn at lumbar levels. Thus, all examined peptidergic afferent input to the LSn appears to originate locally within the spinal cord.

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KW - Somatostatin

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Studies of peptidergic input to the lateral spinal nucleus

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Keywords

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