Subchronic racemic gamma vinyl-GABA produces weight loss in Sprague Dawley and Zucker fatty rats

Amy DeMarco, Reema M. Dalal, Milan Kahanda, Uma Mullapudi, Jessica Pai, Crystie Hammel, Courtney N.B. Liebling, Vinal Patel, Jonathan D. Brodie, Wynne K. Schiffer, Stephen L. Dewey, Stefanie D. Aquilina

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Given the growing obesity epidemic, pressure to develop an effective pharmacologic treatment is mounting. Following the completion of a randomized, double-blind, placebo controlled trial as well as two small open label trials, gamma vinyl-GABA (GVG) has been shown to be safe and effective for treating cocaine and/or methamphetamine dependence. In an extension of these findings, the present study examined whether GVG could produce weight loss in adolescent as well as genetically obese animals. Specifically, adolescent Sprague Dawley and adolescent and adult Zucker fatty rats received GVG at various doses (75-300 mg/kg, i.p., racemic) for treatment periods lasting no longer than 14 consecutive days. GVG produced significant weight loss in a dose dependent fashion in all groups. These effects were marked, as average decreases of 12-20% of original body weight were observed. These findings suggest that GVG may be useful as a treatment for obesity. Further, that these results occurred in genetically obese animals offers the possibility that GVG may even help manage severe obesity resulting from binge-eating, a disorder involving food consumption in a pattern similar to the compulsive drug-seeking behavior observed in cocaine and methamphetamine dependent subjects.

Original languageEnglish (US)
Pages (from-to)870-872
Number of pages3
JournalSynapse
Volume62
Issue number11
DOIs
StatePublished - Nov 2008

Keywords

  • Binge eating disorder
  • GABA
  • Obesity
  • Vigabatrin
  • Zucker fatty rat

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