Substituted pyrroles via olefin cross-metathesis

Timothy J. Donohoe; Nicholas J. Race; John F. Bower; Cedric K.A. Callens

doi:10.1021/ol101681r

Substituted pyrroles via olefin cross-metathesis

Timothy J. Donohoe, Nicholas J. Race, John F. Bower, Cedric K.A. Callens

Research output: Contribution to journal › Article › peer-review

68 Scopus citations

Abstract

Olefin cross-metathesis (CM) provides a short and convenient entry to diverse trans-γ-aminoenones. When exposed to either acid or Heck arylation conditions, these intermediates are converted to mono-, di-, or trisubstituted pyrroles. The value of this chemistry is demonstrated by its application to the tetrasubstituted pyrrole subunit of Atorvastatin.

Original language	English (US)
Pages (from-to)	4094-4097
Number of pages	4
Journal	Organic Letters
Volume	12
Issue number	18
DOIs	https://doi.org/10.1021/ol101681r
State	Published - Sep 17 2010
Externally published	Yes

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title = "Substituted pyrroles via olefin cross-metathesis",

abstract = "Olefin cross-metathesis (CM) provides a short and convenient entry to diverse trans-γ-aminoenones. When exposed to either acid or Heck arylation conditions, these intermediates are converted to mono-, di-, or trisubstituted pyrroles. The value of this chemistry is demonstrated by its application to the tetrasubstituted pyrrole subunit of Atorvastatin.",

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AU - Race, Nicholas J.

AU - Bower, John F.

AU - Callens, Cedric K.A.

PY - 2010/9/17

Y1 - 2010/9/17

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AB - Olefin cross-metathesis (CM) provides a short and convenient entry to diverse trans-γ-aminoenones. When exposed to either acid or Heck arylation conditions, these intermediates are converted to mono-, di-, or trisubstituted pyrroles. The value of this chemistry is demonstrated by its application to the tetrasubstituted pyrrole subunit of Atorvastatin.

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Substituted pyrroles via olefin cross-metathesis

Abstract

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