Subtle actions of 2-amino-4-phosphonobutyrate (APB) on the Off pathway in the mudpuppy retina

Martin S. Arkin, Robert F. Miller

Research output: Contribution to journalArticlepeer-review

40 Scopus citations

Abstract

The principal action of 2-amino-4-phosphonobutyrate (APB) applied to the retina is the elimination of the On-bipolar cell light response. In this study, we report that APB also has more subtle effects; it sometimes enhances Off responses of Off bipolar cells and On, Off, and On-Off inner retina neurons. Possible mechanisms for this enhancement are considered.

Original languageEnglish (US)
Pages (from-to)142-148
Number of pages7
JournalBrain Research
Volume426
Issue number1
DOIs
StatePublished - Nov 17 1987

Bibliographical note

Funding Information:
We thank Paul Coleman for helplul discussion and both Robert Zalutsky and Jerry Gusdorf for technical assistance. This work was supported by funds from Washington University Division of Biology and Biomedical Sciences, NIH RSA Grant GM07200 from the NIGMS, NEI Grant EY03014 and NSF Grant BNS 85-12385.

Keywords

  • Amino acid
  • Aminobutyric acid
  • Glutamate
  • Mudpuppy
  • Retina
  • Retinal ganglion cell
  • Synaptic receptor

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