Abstract
An organ-on-chip (OOC) device for integrated tissue culturing and in vitro testing has been developed and the reconstruction of dynamically perfused full-thickness human skin equivalents (HSEs) that better recapitulate the structure and functionalities of normal human skin was demonstrated. The fine control of the microenvironment enabled improved epidermal morphogenesis and differentiation, and enhanced barrier function. Integrated 3D culturing and integrity/permeability testing were conducted directly on the device, thus overcoming the limitations of conventional cell culture inserts and diffusion cells. This system is scalable towards a high-throughput, automated platform that serves as an alternative to animal studies for drug screening and toxicology.
| Original language | English (US) |
|---|---|
| Title of host publication | 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017 |
| Publisher | Chemical and Biological Microsystems Society |
| Pages | 1121-1122 |
| Number of pages | 2 |
| ISBN (Electronic) | 9780692941836 |
| State | Published - 2020 |
| Externally published | Yes |
| Event | 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017 - Savannah, United States Duration: Oct 22 2017 → Oct 26 2017 |
Publication series
| Name | 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017 |
|---|
Conference
| Conference | 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017 |
|---|---|
| Country/Territory | United States |
| City | Savannah |
| Period | 10/22/17 → 10/26/17 |
Bibliographical note
Funding Information:This research was financially supported by Singapore A*STAR's Joint Council Office, grant no. 1334K00081.
Publisher Copyright:
© 17CBMS-0001.
Keywords
- Hydrogels
- Organ-on-chip
- Skin permeation
- Skin-on-chip
- Tissue engineering