Sustained neuronal activation raises oxidative metabolism to a new steady-state level: Evidence from 1H NMR spectroscopy in the human visual cortex

Research output: Contribution to journalArticlepeer-review

196 Scopus citations

Abstract

To date, functional 1H NMR spectroscopy has been utilized to report the time courses of few metabolites, primarily lactate. Benefiting from the sensitivity offered by ultra-high magnetic field (7 T), the concentrations of 17 metabolites were measured in the human visual cortex during two paradigms of visual stimulation lasting 5.3 and 10.6 mins. Significant concentration changes of approximately 0.2 μmol/g were observed for several metabolites: lactate increased by 23%±5% (P<0.0005), glutamate increased by 3%±1% (P<0.01), whereas aspartate decreased by 15%±6% (P<0.05). Glucose concentration also manifested a tendency to decrease during activation periods. The lactate concentration reached the new steady-state level within the first minute of activation and came back to baseline only after the stimulus ended. The changes of the concentration of metabolites implied a rise in oxidative metabolism to a new steady-state level during activation and indicated that amino-acid homeostasis is affected by physiological stimulation, likely because of an increased flux through the malate-aspartate shuttle.

Original languageEnglish (US)
Pages (from-to)1055-1063
Number of pages9
JournalJournal of Cerebral Blood Flow and Metabolism
Volume27
Issue number5
DOIs
StatePublished - May 16 2007

Keywords

  • BOLD
  • Brain activation
  • Functional metabolism
  • H NMR spectroscopy
  • In vivo
  • Lactate
  • Malate-aspartate shuttle

Fingerprint Dive into the research topics of 'Sustained neuronal activation raises oxidative metabolism to a new steady-state level: Evidence from <sup>1</sup>H NMR spectroscopy in the human visual cortex'. Together they form a unique fingerprint.

Cite this