Aim: To study the swelling characteristic of compound sodium alginate-chitosan gel and its application in slow releasing of drugs. Methods: The granules of compound sodium alginate-chitosan gel were made under mild conditions for studying its swelling kinetics in the pH 1.4 environment of stomach and pH 7.4 of environment of small intestine and the effects of various factors on its swelling characteristic. Ketoprofen microcapsule was made according to the gel's characteristic for detecting its slow releasing effect in the artificial gastric and intestinal fluids. Results: Degree of swelling of the gel was lower in hydrochloric acid buffer of pH 1.4 and was much higher in hydrochloric acid buffer of pH 7.4. Ketoprofen microcapsules made of this kind of gel had significantly slow releasing effect of drugs. Conclusion: The effects of the contents of chitosan, sodium alginate and calcium ion content on the swelling characteristics of the gel was discussed and how to made ketoprofen microcapsules of ideal releasing effect according to the characteristics.
|Original language||English (US)|
|Number of pages||2|
|Journal||Chinese Journal of Clinical Rehabilitation|
|State||Published - Apr 1 2004|