SWIFT detection of SPIO-labeled stem cells grafted in the myocardium

Rong Zhou, Djaudat Idiyatullin, Steen Moeller, Curt Corum, Hualei Zhang, Hui Qiao, Jia Zhong, Michael Garwood

Research output: Contribution to journalArticlepeer-review

55 Scopus citations

Abstract

We report initial results from studies using sweep imaging with Fourier transformation (SWIFT) to detect superparamagnetic iron oxide (SPIO) particle-labeled stem cells in the rat heart. In experiments performed on phantoms containing titanium balls or SPIO-labeled cells, frequency-shifted signals surrounding the paramagnetic objects produced a pileup artifact visualized by SWIFT. Total signal intensity was retained to a much greater extent by SWIFT as compared to gradient echo imaging. SWIFT imaging of excised and in vivo hearts showed (a) reduced blooming artifact as compared with gradient echo imaging, which helped reduce ambiguity in the detection of SPIO-labeled cells; (b) enhancement of off-resonance signals relative to the background in the imaginary component of images; and (c) detailed myocardial anatomy in magnitude images, which provided anatomic reference. These features suggest SWIFT can facilitate the detection of SPIO-laden cells in the cardiovascular system.

Original languageEnglish (US)
Pages (from-to)1154-1161
Number of pages8
JournalMagnetic resonance in medicine
Volume63
Issue number5
DOIs
StatePublished - May 2010

Keywords

  • Cardiac MRI
  • Cellular cardiomyoplasty
  • MRI
  • Myocardial infarction
  • SPIO
  • SWIFT
  • Stem cell
  • Superparamagnetic iron oxide
  • Sweep imaging with Fourier transformation

Fingerprint

Dive into the research topics of 'SWIFT detection of SPIO-labeled stem cells grafted in the myocardium'. Together they form a unique fingerprint.

Cite this