Activated manganese dioxide was found to be an effective reagent for synthesis of estrogen-o-quinones from the corresponding catechols. The isolation and characterization of 1,5(10)-estradiene-3,4,17-trione is described.
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Acknowledgements-The support of NIH Grant (Biomedical Research Support) and a grant from the Graduate School, University of ~inneso~ are gratefully acknowledged. The author is also very grateful to Dr I’. I. Holmes, J. Varghese and J. Yennerstrom for helpful discussions.