Abstract
Major histocompatibility complex (MHC) molecules in the thymus select from the repertoire of germline receptors those that will be most useful in mounting responses to antigen in the periphery. Recent data has shed light on the involvement of self peptides presented by the MHC in this process, and has indicated that a requirement for the constant recognition of 'self' may be essential for T-cell longevity in the periphery.
Original language | English (US) |
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Pages (from-to) | 214-219 |
Number of pages | 6 |
Journal | Current Opinion in Immunology |
Volume | 10 |
Issue number | 2 |
DOIs | |
State | Published - Apr 1998 |