TY - JOUR
T1 - Targeting tumor initiating cells through inhibition of cancer testis antigens and notch signaling
T2 - A hypothesis
AU - Colombo, Michela
AU - Mirandola, Leonardo
AU - Reidy, Adair
AU - Suvorava, Natallia
AU - Konala, Venu
AU - Chiaramonte, Raffaella
AU - Grizzi, Fabio
AU - Rahman, Rakhshanda Layeequr
AU - Jenkins, Marjorie R.
AU - Nugyen, Diane D.
AU - Dalhbeck, Scott
AU - Cobos, Everardo
AU - Figueroa, Jose A.
AU - Chiriva-Internati, Maurizio
N1 - Publisher Copyright:
© 2015 Informa Healthcare USA, Inc.
PY - 2015/3/4
Y1 - 2015/3/4
N2 - Tumor initiating cells (TICs) differ from normal stem cells (SCs) in their ability to initiate tumorigenesis, invasive growth, metastasis and the acquisition of chemo and/or radio-resistance. Over the past years, several studies have indicated the potential role of the Notch system as a key regulator of cellular stemness and tumor development. Furthermore, the expression of cancer testis antigens (CTA) in TICs, and their role in SC differentiation and biology, has become an important area of investigation. Here, we propose a model in which CTA expression and Notch signaling interacts to maintain the sustainability of self-replicating tumor populations, ultimately leading to the development of metastasis, drug resistance and cancer progression. We hypothesize that Notch-CTA interactions in TICs offer a novel opportunity for meaningful therapeutic interventions in cancer.
AB - Tumor initiating cells (TICs) differ from normal stem cells (SCs) in their ability to initiate tumorigenesis, invasive growth, metastasis and the acquisition of chemo and/or radio-resistance. Over the past years, several studies have indicated the potential role of the Notch system as a key regulator of cellular stemness and tumor development. Furthermore, the expression of cancer testis antigens (CTA) in TICs, and their role in SC differentiation and biology, has become an important area of investigation. Here, we propose a model in which CTA expression and Notch signaling interacts to maintain the sustainability of self-replicating tumor populations, ultimately leading to the development of metastasis, drug resistance and cancer progression. We hypothesize that Notch-CTA interactions in TICs offer a novel opportunity for meaningful therapeutic interventions in cancer.
KW - Cancer
KW - Cancer testis antigens
KW - Notch signaling
KW - Stem cells
UR - http://www.scopus.com/inward/record.url?scp=84928536175&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84928536175&partnerID=8YFLogxK
U2 - 10.3109/08830185.2015.1027629
DO - 10.3109/08830185.2015.1027629
M3 - Article
C2 - 25901861
AN - SCOPUS:84928536175
SN - 0883-0185
VL - 34
SP - 188
EP - 199
JO - International Reviews of Immunology
JF - International Reviews of Immunology
IS - 2
ER -
