TY - JOUR
T1 - Taxol photoaffinity labels 2. Synthesis and biological evaluation of N-(4-azidobenzoyl)-N-debenzoyltaxol, N-(4-azido-2,3,5,6-tetrafluorobenzoyl)-N-debenzoyltaxol, and 7-(4-azido-2,3,5,6-tetrafluorobenzoyl)taxol
AU - Georg, Gunda I.
AU - Harriman, Geraldine C B
AU - Park, Haeil
AU - Himes, Richard H.
PY - 1994/2/10
Y1 - 1994/2/10
N2 - Biologically active photoaffinity labeled analogues of taxol (6, 8 and 9) have been synthesized utilizing (3R,4S)-3-hydroxy-4-phenyl-2-azetidinones, produced via the ester enolate-imine cyclocondensation reaction, and the diterpene baccatin III (2). Photoaffinity label 8 proved to be the most active taxol photoaffinity label synthesized to date in addition to having the most similar structure to that of the parent, taxol.
AB - Biologically active photoaffinity labeled analogues of taxol (6, 8 and 9) have been synthesized utilizing (3R,4S)-3-hydroxy-4-phenyl-2-azetidinones, produced via the ester enolate-imine cyclocondensation reaction, and the diterpene baccatin III (2). Photoaffinity label 8 proved to be the most active taxol photoaffinity label synthesized to date in addition to having the most similar structure to that of the parent, taxol.
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U2 - 10.1016/0960-894X(94)80022-7
DO - 10.1016/0960-894X(94)80022-7
M3 - Article
AN - SCOPUS:0028258731
SN - 0960-894X
VL - 4
SP - 487
EP - 490
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
IS - 3
ER -