TY - JOUR
T1 - Ten years after
T2 - Reclassification of steroid-responsive genes
AU - Dean, Diane M.
AU - Sanders, Michel M
PY - 1996/12/17
Y1 - 1996/12/17
N2 - Although several hundred genes are directly or indirectly regulated by steroid hormones, significant gaps exist in our understanding of the relevant mechanisms, particularly for those genes that do not directly bind intracellular receptors or that exhibit delayed changes in transcription rates upon receptor binding. To assist in defining the mechanism of action of steroid hormones, we are proposing that a standard nomenclature be adopted for classifying steroid-responsive genes, based upon whether the receptors directly bind to the target genes and the kinetics of the response. Three categories are proposed: primary response genes, delayed primary response genes, and secondary response genes.
AB - Although several hundred genes are directly or indirectly regulated by steroid hormones, significant gaps exist in our understanding of the relevant mechanisms, particularly for those genes that do not directly bind intracellular receptors or that exhibit delayed changes in transcription rates upon receptor binding. To assist in defining the mechanism of action of steroid hormones, we are proposing that a standard nomenclature be adopted for classifying steroid-responsive genes, based upon whether the receptors directly bind to the target genes and the kinetics of the response. Three categories are proposed: primary response genes, delayed primary response genes, and secondary response genes.
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U2 - 10.1210/me.10.12.1489
DO - 10.1210/me.10.12.1489
M3 - Short survey
C2 - 8961259
AN - SCOPUS:0029994198
SN - 0888-8809
VL - 10
SP - 1489
EP - 1495
JO - Molecular Endocrinology
JF - Molecular Endocrinology
IS - 12
ER -