TY - JOUR
T1 - The amino acid composition of proteins
T2 - A method of analysis
AU - Cook, R. Dennis
AU - Nassar, R. F.
PY - 1975/2
Y1 - 1975/2
N2 - Four quasiloglinear models are proposed for describing relationships between the amino acid composition of proteins and the structure of the genetic code. The models allow estimation of base frequencies in all three codon positions and can be used to investigate "interactions" between any two codon positions. The estimation procedure proposed by Ohta and Kimura (Genetics 64 (1970), 387-395) is discussed and using two of the proposed quasiloglinear models an analysis of the amino acid composition of human cytochrome c is presented. The analysis suggests that of the six codons which code for leucine (CUU, CUC, CUA and CUG) do not occur in human cytochrome c.
AB - Four quasiloglinear models are proposed for describing relationships between the amino acid composition of proteins and the structure of the genetic code. The models allow estimation of base frequencies in all three codon positions and can be used to investigate "interactions" between any two codon positions. The estimation procedure proposed by Ohta and Kimura (Genetics 64 (1970), 387-395) is discussed and using two of the proposed quasiloglinear models an analysis of the amino acid composition of human cytochrome c is presented. The analysis suggests that of the six codons which code for leucine (CUU, CUC, CUA and CUG) do not occur in human cytochrome c.
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U2 - 10.1016/0040-5809(75)90006-4
DO - 10.1016/0040-5809(75)90006-4
M3 - Article
C2 - 165586
AN - SCOPUS:0016465493
SN - 0040-5809
VL - 7
SP - 64
EP - 83
JO - Theoretical Population Biology
JF - Theoretical Population Biology
IS - 1
ER -