The antidepressant drug, sertraline, hinders bone healing and osseointegration in rats’ tibiae

Lina Abu Nada; Ahmed Al Subaie; Alaa Mansour; Xixi Wu; Mohamed Nur Abdallah; Haider Al-Waeli; Ala Ersheidat; Laura S. Stone; Monzur Murshed; Faleh Tamimi

doi:10.1111/jcpe.13015

The antidepressant drug, sertraline, hinders bone healing and osseointegration in rats’ tibiae

Lina Abu Nada, Ahmed Al Subaie, Alaa Mansour, Xixi Wu, Mohamed Nur Abdallah, Haider Al-Waeli, Ala Ersheidat, Laura S. Stone, Monzur Murshed, Faleh Tamimi

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Aim: Selective serotonin reuptake inhibitors (SSRIs) are one of the most common antidepressant drugs. SSRI use is associated with increased risk of bone fracture and titanium implant failure. The aim of this in vivo study was to investigate the effect of SSRIs on osseointegration and bone healing. Materials and Methods: On a total of 24 Sprague-Dawley rats, a custom-made titanium implant was placed in the left tibia, while a unicortical defect was created in the right tibia. Rats were assigned randomly into two groups and received a daily dose of either sertraline (5 mg/kg) or saline. After two weeks, they were euthanized and bone healing and osseointegration were assessed by micro-CT and histology. Results: Bone formation in bone defects was significantly lower (p < 0.05) in sertraline-treated rats (BV/TV = 20.67 ± 11.98%) compared to the controls (BV/TV = 37.87 ± 9.56%). Furthermore, the percentage of osseointegration was significantly lower (p < 0.05) in sertraline-treated rats (34.40 ± 7.17%) compared to the controls (54.37 ± 8.58%). Conclusion: Sertraline hinders bone healing and implant osseointegration.

Original language	English (US)
Pages (from-to)	1485-1497
Number of pages	13
Journal	Journal of clinical periodontology
Volume	45
Issue number	12
DOIs	https://doi.org/10.1111/jcpe.13015
State	Published - Dec 2018
Externally published	Yes

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Publisher Copyright:
© 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd

Keywords

bone healing
cytokine
osseointegration
proteome
selective serotonin reuptake inhibitors
sertraline

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title = "The antidepressant drug, sertraline, hinders bone healing and osseointegration in rats{\textquoteright} tibiae",

abstract = "Aim: Selective serotonin reuptake inhibitors (SSRIs) are one of the most common antidepressant drugs. SSRI use is associated with increased risk of bone fracture and titanium implant failure. The aim of this in vivo study was to investigate the effect of SSRIs on osseointegration and bone healing. Materials and Methods: On a total of 24 Sprague-Dawley rats, a custom-made titanium implant was placed in the left tibia, while a unicortical defect was created in the right tibia. Rats were assigned randomly into two groups and received a daily dose of either sertraline (5 mg/kg) or saline. After two weeks, they were euthanized and bone healing and osseointegration were assessed by micro-CT and histology. Results: Bone formation in bone defects was significantly lower (p < 0.05) in sertraline-treated rats (BV/TV = 20.67 ± 11.98%) compared to the controls (BV/TV = 37.87 ± 9.56%). Furthermore, the percentage of osseointegration was significantly lower (p < 0.05) in sertraline-treated rats (34.40 ± 7.17%) compared to the controls (54.37 ± 8.58%). Conclusion: Sertraline hinders bone healing and implant osseointegration.",

keywords = "bone healing, cytokine, osseointegration, proteome, selective serotonin reuptake inhibitors, sertraline",

author = "{Abu Nada}, Lina and {Al Subaie}, Ahmed and Alaa Mansour and Xixi Wu and Abdallah, {Mohamed Nur} and Haider Al-Waeli and Ala Ersheidat and Stone, {Laura S.} and Monzur Murshed and Faleh Tamimi",

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year = "2018",

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doi = "10.1111/jcpe.13015",

language = "English (US)",

volume = "45",

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AU - Abu Nada, Lina

AU - Al Subaie, Ahmed

AU - Mansour, Alaa

AU - Wu, Xixi

AU - Abdallah, Mohamed Nur

AU - Al-Waeli, Haider

AU - Ersheidat, Ala

AU - Stone, Laura S.

AU - Murshed, Monzur

AU - Tamimi, Faleh

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The antidepressant drug, sertraline, hinders bone healing and osseointegration in rats’ tibiae

Abstract

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Keywords

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