The chemistry of tryptanthrin and its derivatives

Ashli M. Tucker, Peter Grundt

Research output: Contribution to journalReview articlepeer-review

37 Scopus citations


Tryptanthrin (indolo[2,1-b]quinazoline-6,12-dione) is a natural product which shows significant biological activity as an antibacterial, antiparasitic, and antineoplastic agent. Historically, tryptanthrin has been found as a component of many dyes as well as a constituent of medicinal herbal treatments. This review describes the synthesis of tryptanthrin and some related compounds which also have a quinazoline ring fused to an indolo moiety as a core.

Original languageEnglish (US)
Pages (from-to)546-569
Number of pages24
Issue number1
StatePublished - Jul 29 2012


  • Alkaloids
  • Indoles fused
  • Quinazolines fused
  • Tryptanthrin

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