The effect of pegylated interferonα2b and ribavirin on posttraumatic stress disorder symptoms

Eric Dieperink, Jennie Leskela, Michael E. Dieperink, Blake Evans, Paul Thuras, Samuel B. Ho

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Background: Patients with chronic psychiatric diagnoses have a prevalence of chronic hepatitis C (HCV) approximately 11 times higher than the general American population. Posttraumatic stress disorder (PTSD) is particularly common among HCV patients. Objective: The authors describe the effect of treatment with pegylated-interferon-α2b (IFN) and ribavirin for patients with HCV on their posttraumatic stress disorder (PTSD) symptoms. Method: Sixteen patients with HCV and combat-related PTSD were followed for 24 weeks and assessed with self-report measures of PTSD, hostility, and depression. Results: Depression and Resentment scores significantly increased in five patients treated with IFN and ribavirin, but no significant differences were found in PTSD scores when compared with 11 control patients. Conclusion: The results suggest that patients with PTSD and HCV can be safely treated with anti-viral therapies when they are given appropriate psychiatric care.

Original languageEnglish (US)
Pages (from-to)225-229
Number of pages5
Issue number3
StatePublished - 2008
Externally publishedYes

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