The effect of serum proteins and hydrophilic polymers on the transport of model lung surfactant

Patrick C. Stenger, Jonathan G. Fernsler, Joseph A. Zasadzinski

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Inactivation of model lung surfactant (LS) by serum proteins and subsequent inactivation reversal by hydrophilic polymers is investigated with a Langmuir trough and quantitative Brewster angle microscopy. These experiments are compared with a novel LS transport theory based on slow flocculation of colloidal particles with a potential energy barrier. While the serum proteins increase the energy barrier due to steric and electrostatic effects, the polymers generate a depletion potential to reduce the energy barrier. An experimental determination of the optimum polymer concentration for inhibition reversal demonstrates the need to consider both the scaling of depletion forces and the polymer overlap concentration. This work has applications in developing a next-generation, inactivation-resistant LS which will serve as therapy for lung diseases such as Acute Respiratory Distress Syndrome and asthma.

Original languageEnglish (US)
Title of host publication05AIChE
Subtitle of host publication2005 AIChE Annual Meeting and Fall Showcase, Conference Proceedings
Number of pages1
StatePublished - Dec 1 2005
Event05AIChE: 2005 AIChE Annual Meeting and Fall Showcase - Cincinnati, OH, United States
Duration: Oct 30 2005Nov 4 2005

Other

Other05AIChE: 2005 AIChE Annual Meeting and Fall Showcase
CountryUnited States
CityCincinnati, OH
Period10/30/0511/4/05

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