Abstract
The IGF system components have been implicated in breast cancer progression. IGF-I and IGF-II are mitogenic and anti-apoptotic peptides that influence the proliferation of various cell types including normal and transformed breast epithelial cells. The IGF system is a key growth regulatory pathway in breast cancer. As various components of the IGF system have been directly or indirectly implicated in breast cancer, it is essential to gain a better understanding of these in order to develop more specific therapeutic strategies for treating breast cancer.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 197-209 |
| Number of pages | 13 |
| Journal | Endocrine-related cancer |
| Volume | 8 |
| Issue number | 3 |
| DOIs | |
| State | Published - 2001 |
