Functional reconstruction of an occlusion with severe residual ridge resorption is a clinical challenge. Removable prostheses are unsuccessful in situations with severe bone resorption. A patient with an edentulous maxilla received bone grafts from the anterior iliac crest to augment the maxillary alveolar residual ridges. The maxilla underwent bilateral sinus lift in the posterior area and onlay bone graft on the anterior maxilla using platelet-rich plasma. Eight endosseous implants were placed using a CAD/CAM surgical template approximately 6 months after the bone augmentation procedure. A prefabricated definitive implant-supported fixed complete denture was connected immediately after implant placement using a CAD/CAM-guided surgical implant placement protocol. (J Prosthet Dent 2008;99:85-90).