Abstract
Central nervous system (CNS) relapse is a common cause of treatment failure in patients with acute lymphoblastic leukaemia (ALL) despite current CNS-directed therapies that are also associated with significant short- and long-term toxicities. Herein, we showed that leukaemia cells exhibit decreased proliferation, elevated reactive oxygen species (ROS) and increased cell death in cerebral spinal fluid (CSF) both in vitro and in vivo. However, interactions between leukaemia and meningeal cells mitigated these adverse effects. This work expands our understanding of the pathophysiology of CNS leukaemia and suggests novel therapeutic approaches for more effectively targeting leukaemia cells in the CNS.
Original language | English (US) |
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Pages (from-to) | 513-517 |
Number of pages | 5 |
Journal | British journal of haematology |
Volume | 189 |
Issue number | 3 |
DOIs | |
State | Published - May 1 2020 |
Bibliographical note
Publisher Copyright:© 2020 British Society for Haematology and John Wiley & Sons Ltd
Keywords
- acute lymphpoblastic leukaemia
- cell adhesion
- cell death
- central nervous system
- cerebral spinal fluid