The neurobiological characteristics of rapid eye movement (REM) sleep are candidate endophenotypes of depression, schizophrenia, mental retardation and dementia

Claude Gottesmann; Irving Gottesman

doi:10.1016/j.pneurobio.2007.01.004

The neurobiological characteristics of rapid eye movement (REM) sleep are candidate endophenotypes of depression, schizophrenia, mental retardation and dementia

Claude Gottesmann, Irving Gottesman

Psychiatry & Behavioral Sciences

Research output: Contribution to journal › Review article › peer-review

102 Scopus citations

Abstract

Animal models are a promising method to approach the basic mechanisms of the neurobiological disturbances encountered in mental disorders. Depression is characterized by a decrease of REM sleep latency and an increase of rapid eye movement density. In schizophrenia, electrophysiological, tomographic, pharmacological and neurochemical activities are all encountered during REM sleep. Mental retardation and dementia are characterized by rather specific REM sleep disturbances. Identification of the genetic support for these abnormalities (endophenotypes) encountered during REM sleep could help to develop specific treatments.

Original language	English (US)
Pages (from-to)	237-250
Number of pages	14
Journal	Progress in Neurobiology
Volume	81
Issue number	4
DOIs	https://doi.org/10.1016/j.pneurobio.2007.01.004
State	Published - Mar 1 2007

Keywords

Dreaming
Mental illness
Paradoxical sleep

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AB - Animal models are a promising method to approach the basic mechanisms of the neurobiological disturbances encountered in mental disorders. Depression is characterized by a decrease of REM sleep latency and an increase of rapid eye movement density. In schizophrenia, electrophysiological, tomographic, pharmacological and neurochemical activities are all encountered during REM sleep. Mental retardation and dementia are characterized by rather specific REM sleep disturbances. Identification of the genetic support for these abnormalities (endophenotypes) encountered during REM sleep could help to develop specific treatments.

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The neurobiological characteristics of rapid eye movement (REM) sleep are candidate endophenotypes of depression, schizophrenia, mental retardation and dementia

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