TY - JOUR
T1 - The New York High-Risk Project
T2 - Prevalence and comorbidity of Axis I disorders in offspring of schizophrenic parents at 25-year follow-up
AU - Erlenmeyer-Kimling, L.
AU - Adamo, Ulla Hilldoff
AU - Rock, Donald
AU - Roberts, Simone A.
AU - Bassett, Anne S.
AU - Squires-Wheeler, Elisabeth
AU - Cornblatt, Barbara A.
AU - Endicott, Jean
AU - Pape, Sky
AU - Gottesman, Irving I.
PY - 1997
Y1 - 1997
N2 - Background: The New York High-Risk Project is a study of offspring of patients with schizophrenia (HRSz group) or affective illness (HRAff group) and psychiatrically normal parents (NC group) observed prospectively from childhood to adulthood. We herein present lifetime prevalence and comorbidity rates of Axis I disorders in subjects and their siblings from sample A of the project. Methods: Schedule for Affective Disorders and Schizophrenia-Lifetime Version interviews conducted with the offspring in adulthood were used to obtain diagnoses of Axis I disorders. Results: Schizophrenia and unspecified psychoses occurred only in the HRSz group. However, schizoaffective and psychotic affective disorders occurred equally in the HRSz and HRAff groups. Total rates of psychosis in these groups were significantly higher than in the NC group. All groups had similar rates of nonpsychotic affective and substance abuse disorders. The HRAff group, however, had significantly more total affective illness than the NC group and tended to have more anxiety disorders than the other groups. Comorbidity rates in the HRSz and HRAff groups were nearly twice those of the NC group. Conclusions: The familial liabilities to schizophrenia and affective disorders show specificities and commonalities, differing markedly from each other in their expression of some disorders and sharing others. Patterns of comorbidity are generally, although not entirely, similar to these liabilities.
AB - Background: The New York High-Risk Project is a study of offspring of patients with schizophrenia (HRSz group) or affective illness (HRAff group) and psychiatrically normal parents (NC group) observed prospectively from childhood to adulthood. We herein present lifetime prevalence and comorbidity rates of Axis I disorders in subjects and their siblings from sample A of the project. Methods: Schedule for Affective Disorders and Schizophrenia-Lifetime Version interviews conducted with the offspring in adulthood were used to obtain diagnoses of Axis I disorders. Results: Schizophrenia and unspecified psychoses occurred only in the HRSz group. However, schizoaffective and psychotic affective disorders occurred equally in the HRSz and HRAff groups. Total rates of psychosis in these groups were significantly higher than in the NC group. All groups had similar rates of nonpsychotic affective and substance abuse disorders. The HRAff group, however, had significantly more total affective illness than the NC group and tended to have more anxiety disorders than the other groups. Comorbidity rates in the HRSz and HRAff groups were nearly twice those of the NC group. Conclusions: The familial liabilities to schizophrenia and affective disorders show specificities and commonalities, differing markedly from each other in their expression of some disorders and sharing others. Patterns of comorbidity are generally, although not entirely, similar to these liabilities.
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U2 - 10.1001/archpsyc.1997.01830240052008
DO - 10.1001/archpsyc.1997.01830240052008
M3 - Article
C2 - 9400345
AN - SCOPUS:15644377772
SN - 0003-990X
VL - 54
SP - 1096
EP - 1102
JO - Archives of General Psychiatry
JF - Archives of General Psychiatry
IS - 12
ER -