TY - JOUR
T1 - The nuclear protein UHRF2 is a direct target of the transcription factor E2F1 in the induction of apoptosis
AU - Lu, Huarui
AU - Hallstrom, Timothy C.
PY - 2013/8/16
Y1 - 2013/8/16
N2 - Background: E2F1-induced apoptosis kills oncogene-stressed cells, and regulators of this process may act as tumor suppressors. Results: We identified UHRF2 in a functional screen for mediators of E2F1 induced apoptosis. Conclusion: UHRF2 binds directly to E2F1 and is required for E2F1 induction of apoptosis and expression of several important apoptosis inducers. Significance: UHRF2 is a suspected tumor suppressor and our work suggests an anti-tumor mechanism.
AB - Background: E2F1-induced apoptosis kills oncogene-stressed cells, and regulators of this process may act as tumor suppressors. Results: We identified UHRF2 in a functional screen for mediators of E2F1 induced apoptosis. Conclusion: UHRF2 binds directly to E2F1 and is required for E2F1 induction of apoptosis and expression of several important apoptosis inducers. Significance: UHRF2 is a suspected tumor suppressor and our work suggests an anti-tumor mechanism.
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U2 - 10.1074/jbc.M112.447276
DO - 10.1074/jbc.M112.447276
M3 - Article
C2 - 23833190
AN - SCOPUS:84882297904
SN - 0021-9258
VL - 288
SP - 23833
EP - 23843
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 33
ER -
