Background: The risk of atherothrombosis is a large health care burden worldwide. With its global prevalence, there is a need to understand all the associated risk factors, both old and new, and their interdependencies in the development of this complex disease leading to myocardial infarction, ischemic stroke, and vascular death and, thus, the major cause of mortality throughout the world. Methods: The REACH Registry sought to compile an international data set to extend our knowledge of atherothrombotic risk factors and ischemic events in the outpatient setting. The Registry will recruit approximately 68 000 outpatients in 44 countries across 6 major regions (Latin America, North America, Europe, Asia, the Middle East, and Australia) from >5000 physician outpatient practices. Patients aged ≥45 years with at least 3 atherothrombotic risk factors or documented cerebrovascular, coronary artery, or peripheral arterial disease will be enrolled. Medical history, risk factors, demographic information, and management will be collected at baseline, and clinical events that occur during the follow-up period of up to 2 years in duration will be recorded. Conclusion: The REACH Registry offers an opportunity to provide a better understanding of the prevalence and clinical consequences of atherothrombosis in the outpatient setting in a wide range of patients from different parts of the world.
Bibliographical noteFunding Information:
REACH Registry Scientific Council Members P Gabriel Steg, MD, Hôpital Bichat-Claude Bernard, Paris, France (Cochair) Deepak L. Bhatt, MD, Cleveland Clinic Foundation, Cleveland, OH (Cochair) E Magnus Ohman, MD, Duke University Medical Center, Durham, NC Joachim Röther, MD, PhD, Klinikum Minden, Minden, Germany Peter WF Wilson, MD, Medical University of South Carolina, Charleston, SC REACH Registry Publication Committee Deepak L. Bhatt, MD, Cleveland Clinic Foundation, Cleveland, OH Shinya Goto, MD, DMedSci, Tokai University School of Medicine, Kanagawa, Japan Alan T. Hirsch, MD, University of Minnesota School of Public Health, Minneapolis, MN Chiau-Suong Liau, MD, PhD, Taiwan University Hospital and College of Medicine, Taipei, Taiwan Jean-Louis Mas, MD, Centre Raymond Garcin, Paris, France E Magnus Ohman, MD, Duke University Medical Center, Durham, NC Joachim Röther, MD, PhD, Klinikum Minden, Minden, Germany P Gabriel Steg, MD, Hôpital Bichat-Claude Bernard, Paris, France Peter WF Wilson, MD, Medical University of South Carolina, Charleston, SC National Coordinators Australia Christopher Reid BA, DipEd, MSc, CertHealthEcon, Phd, Monash University, Victoria, Australia Austria Franz Aichner, MD, Landesnervenklinik Wagner Jauregg, Linz, Austria Thomas Wascher, MD, Universitat Klinikum für Innere Medizin, Graz, Austria Belgium Patrice Laloux, MD, Cliniques Universitaires UCL, Mont-Godinne, Belgium Brazil Denilson Campos de Albuquerque, MD, State University of Rio de Janeiro, Rio de Janeiro, Brazil Bulgaria Julia Jorgova, MD, University Hospital St Ekaterina, Sofia, Bulgaria Canada Eric Cohen, BSc, MD, FRCP (C), Sunnybrook & Women’s College HSC, Toronto, Canada Chile Ramon Corbalan, MD, Hospital Clinico Pontificia Universidad Catolica de Chile, Santiago, Chile China Chuanzhen LV, Huashan Hospital, Shanghai, China Runlin Gao, MD, Fuwai Hospital, Beijing, China Denmark Per Hildebrandt, MD, H:S Frederiksberg Hospital, Frederiksberg, Denmark France Jean-Louis Mas, MD, Hôpital Saint-Anne, Paris, France Patrice Cacoub, MD, Groupe Hopitalier Universitaire Pitié Salpêtrière, Paris, France Gilles Montalescot, MD, PhD, Groupe Hopitalier Universitaire Pitié Salpêtrière, Paris, France Germany Klaus Parhofer, MD, Universitätsklinikum Großhadern, Munich, Germany Jochum Senges, MD, Klinikum Ludwigshafen, Ludwigshafen, Germany Uwe Zeymer, MD, Universität-Klinikum Hamburg Eppendorf, Hamburg, Germany Joachim Röther, MD, Klinikum Minden, Minden, Germany Greece Moses Elisaf, MD, FRSH, University of Ioannina, Ioannina, Greece Guatemala Romulo López, MD Centro Diagnostico, Cuidad de Guatemala, Guatemala Hong Kong Juliana Chan, MD, Prince of Wales Hospital, Shatin, Hong Kong Hungary György Pfliegler, MD, University of Debrecen Medical and Health Science Center, Debrecen, Hungary Indonesia Bambang Sutrisna, MD MHSc, University of Indonesia, Jakarta, Indonesia Israel Avi Porath, MD, Soroka Medical Center, Beer Sheva, Israel Japan Yasuo Ikeda, MD, Keio University School of Medicine, Tokyo, Japan Lebanon Ismail Khalil, MD, American University Hospital Hamra, Beirut, Lebanon Lithuania Ruta Babarskiene, MD, University Hospital, Kaunas, Lithuania Malaysia Robaayah Zambahari, MBBS, MRCP, FRCP, FACC, Institute Jantung Negara, Kuala Lumpur, Malaysia Mexico Efrain Gaxiola, MD, Instituto Cardiovascular de Guadalajara, Jalisco, Mexico The Netherlands Don Poldermans, MD, Erasmus Medisch Centrum, Rotterdam, The Netherlands Philippines Teresa Abola, MD, Philippine Heart Center, Quezon City, Philippines Portugal Victor Gil, MD, Hospital de Santa Cruz, Carnaxide, Portugal Romania Constantin Popa, MD, Institutul de Boli Cerebro-Vasculare, Bucharest, Romania Russia Yuri Belenkov, MD, Cardiology Research Complex, Moscow, Russia Elizaveta Panchenko Pavlovna, MD, Cardiology Research Complex, Moscow, Russia Saudi Arabia Hassan Chamsi-Pasha, MD, FRCP, FACC, King Fahd Military Hospital, Jeddah, Kingdom of Saudi Arabia Singapore Yeo Tiong Cheng, MD, MRCP, National University Hospital, Singapore South Korea Oh Dong-Joo, MD, Korea Hospital, Seoul, South Korea Spain Carmen Suàrez, MD, Hospital de la Princesa, Madrid, Spain Switzerland Iris Baumgartner, MD, Universität Spital Bern, Bern, Switzerland Taiwan Chiau-Suong Liau, MD, PhD, National Taiwan University Hospital, Taipei, Taiwan Thailand Piyamitr Sritara, MD, Ramathibodi Hospital, Bangkok, Thailand United Arab Emirates Wael Mahameed, MD, Abu Dhabi, United Arab Emirates United Kingdom Jonathan Morrell, MB BChir, FRCGP, DCH, DRCOG, The Conquest Hospital, Hastings, United Kingdom Ukraine Vira Tseluyko, MD, Kharkov, Ukraine USA Christopher Cannon, MD, Brigham's and Women Hospital, Boston, MA Robert Califf, MD, Duke University Medical Center, Durham, NC Mark Alberts, MD, Northwestern University Medical Center, Chicago, IL Alan Hirsch, MD, University of Minnesota Medical School, Minneapolis, MN Kim Eagle, MD, University of Michigan, Ann Arbor, MI Statistician Alain-Jean Richard, MD, PhD, Sanofi-Aventis, Paris, France Sponsors Veronique Daclin, MD, Sanofi-Aventis, Paris, France Ingmar Wahlqvist, Sanofi-Aventis, Paris, France Brian Gavin, PhD, Bristol-Myers Squibb, Plainsboro, NJ Jean-Christophe Pointeau, Bristol-Myers Squibb, Plainsboro, NJ