The role of STAT5 in the development, function, and transformation of B and T lymphocytes

Lynn M. Heltemes-Harris; Mark J.L. Willette; Kieng B. Vang; Michael A. Farrar

doi:10.1111/j.1749-6632.2010.05907.x

The role of STAT5 in the development, function, and transformation of B and T lymphocytes

Lynn M. Heltemes-Harris, Mark J.L. Willette, Kieng B. Vang, Michael A. Farrar

Laboratory Medicine and Pathology

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33 Scopus citations

Abstract

The transcription factor signal transducer and activator of transcription 5 (STAT5) is activated by a number of cytokine and growth hormone receptors and plays a key role in the development and function of many organ systems. In this review, we focus on recent discoveries about the role of STAT5 in the development and function of B and T lymphocytes. Of particular interest is the growing appreciation for the function of STAT5 as a transcriptional repressor. Finally, we discuss recent discoveries about the role of STAT5 in transformation of B and T lymphocytes.

Original language	English (US)
Pages (from-to)	18-31
Number of pages	14
Journal	Annals of the New York Academy of Sciences
Volume	1217
Issue number	1
DOIs	https://doi.org/10.1111/j.1749-6632.2010.05907.x
State	Published - Jan 2011

Keywords

Leukemia
Lymphocyte development
Lymphoma
STAT5
Transformation

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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The role of STAT5 in the development, function, and transformation of B and T lymphocytes

Abstract

Keywords

UN SDGs

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