The special effect of fluoride on the chromatography of acidic analytes on polybutadiene-coated zirconia

Y. Hu, P. W. Carr

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

The special effect of fluoride as a Lewis base additive in suppressing the ligand-exchange inter-actions for acidic analytes on polybutadiene-coated zirconia (PBD-ZrO2) has been investigated. We found that fluoride is more effective than phosphate in improving the separation efficiency for strong acids. The improvement is attributed to that fluoride has a smaller size and a more flexible coordination chemistry towards zirconium centers than phosphate; consequently, fluoride can more effectively improve the kinetics of the ligand-exchange processes for strongly acidic analytes. We demonstrated that using a small amount of fluoride in combination with a larger quantity of phosphate is a practical way to improve the separation efficiency and resolution for acidic analytes. Some example separations are presented.

Original languageEnglish (US)
Pages (from-to)439-444
Number of pages6
JournalChromatographia
Volume56
Issue number7-8
DOIs
StatePublished - Oct 2002

Keywords

  • Acidic analytes
  • Column liquid chromatography
  • Fluoride eluent
  • Ligand-exchange interaction
  • Polybutadiene - coated zirconia

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