The TCR ADAPts to integrin-mediated cell adhesion

Research output: Contribution to journalReview articlepeer-review

32 Scopus citations

Abstract

Adapter proteins regulate leukocyte signal transduction through recruitment of effector molecules to multiprotein complexes. Recent studies in Adhesion and Degranulation promoting Adapter Protein (ADAP)-deficient mice have established that the cytoplasmic phosphoprotein ADAP is required for optimal, mature T-cell proliferation. Furthermore, ADAP plays a key role in T-cell antigen receptor (TCR)-mediated 'inside out' signaling leading to integrin activation and to enhanced cellular adhesion to integrin ligands. ADAP associates physically with molecules known to play roles in the regulation of TCR-stimulated actin polymerization. These associations support the hypothesis that ADAP functions in actin cytoskeletal reorganization leading to cellular adhesion and activation.

Original languageEnglish (US)
Pages (from-to)113-121
Number of pages9
JournalImmunological Reviews
Volume192
DOIs
StatePublished - Apr 2003

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