Abstract
Transgenic technology has made it possible to alter the genetic make-up of a laboratory mouse through the removal or insertion of selected genes. The resulting transgenic mouse provides a means for determining the developmental and functional contributions of selected genes and the proteins they encode. The current article reviews examples of the use of transgenic mice in pharmacokinetic and pharmacodynamic studies. In addition to examining current applications of transgenic technology in the areas of pharmacokinetics and pharmacodynamics, the potential for future advancements as well as limitations of the technology are discussed.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 422-435 |
| Number of pages | 14 |
| Journal | Journal of Pharmaceutical Sciences |
| Volume | 90 |
| Issue number | 4 |
| DOIs | |
| State | Published - 2001 |
Bibliographical note
Funding Information:The authors acknowledge the research support provided by USPHS grants RO3‐AG17294 (DWM) and R29‐CA75466 (WFE) and the Nebraska Research Initiative.
Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
Keywords
- Knockout
- Pharmacodynamics
- Pharmacokinetics
- Transgenic mouse